Huperzine A ｜120786-18-7
Nkọwa ngwaahịa:
Huperzine A bụ ihe nkwalite ọgụgụ isi nke na-egbochi enzymes na-emebi mmụta neurotransmitter acetylcholine. Ọ bụ nke klaasị cholinergic nke ụmụ irighiri ihe nwere ike inye aka luso mbelata ọgụgụ isi na ndị agadi.
Huperzine A bụ ngwakọta ewepụtara na ezinụlọ huperzine. A na-akpọ ya acetylcholinesterase inhibitor, nke pụtara na ọ na-egbochi enzyme ahụ ka ọ ghara imebi acetylcholine, na-eduga na mmụba nke acetylcholine.
A na-akpọ acetylcholine onye mmụta neurotransmitter ma na-etinyekwa aka na mkpụkọ akwara.
Huperzine A na-egosi na ọ bụ ogige dị oke nchebe. Nsi na ọmụmụ mmadụ sitere na ọmụmụ anụmanụ egosila na ọ nweghị mmetụta ọ bụla na usoro mgbakwunye omenala. A na-ejikwa Huperzine A na nnwale mbido iji gbochie ọrịa Alzheimer.
Huperzine A na-apụta na mmiri cerebrospinal ma na-agafe ihe mgbochi ụbụrụ ọbara n'ụzọ dị mfe.
Huperzine A kacha mara amara dị ka ihe mgbochi acetylcholinesterase. Karịsịa, ọ na-egbochi ụdị G4 nke acetylcholinesterase, nke a na-ahụkarị na ụbụrụ mammalian. Ọ dị irè karị ma ọ bụ dị irè megide ndị ọzọ inhibitors acetylcholinesterase, dị ka tacillin ma ọ bụ rivastatin. Dị ka onye na-egbochi ya, ọ nwere oke mmekọrịta maka acetylcholinesterase. N'otu oge ahụ, ọ na-enwe nkwụsịtụ nwayọọ nwayọọ, nke na-eme ka ọkara ndụ ya dị ogologo.
Na mgbakwunye na igbochi acetylcholinesterase, a pụkwara ịhụ ya dị ka neuroprotective megide glutamate, beta amyloid pigmentation, na H2O2 na-akpata nsị.
Huperzine A nwere ike ịkwalite mmụba nke mkpụrụ ndụ akwara hippocampal (NSC). Ọ dị ka ọ na-akwalite uto irighiri akwara na usoro ihe metụtara bio.
