Uridine | 58-96-8

Uridine bụ pyrimidine nucleoside nke na-eje ozi dị ka ihe mgbochi ụlọ maka RNA (ribonucleic acid), otu n'ime isi ụdị abụọ nke nucleic acid dị mkpa maka nchekwa na nnyefe nke ozi mkpụrụ ndụ ihe nketa na sel.

Nhazi kemịkalụ: Uridine nwere uracil nke pyrimidine nke etinyere na ribose shuga carbon ise site na njikọ β-N1-glycosidic.

Ọrụ ndu:

Mgbochi Owuwu RNA: Uridine bụ akụkụ dị oke mkpa nke RNA, ebe ọ na-etolite ọkpụkpụ azụ nke mkpụrụ ndụ RNA n'akụkụ ndị ọzọ nucleosides dị ka adenosine, guanosine, na cytidine.

Messenger RNA (mRNA): Na mRNA, uridine residues na-edekọ ozi mkpụrụ ndụ ihe nketa n'oge ederede, na-ebu ntuziaka sitere na DNA gaa na igwe njikọ protein dị na cell.

Nyefee RNA (tRNA): Uridine dịkwa na ụmụ irighiri ihe intRNA, ebe ọ na-ekere òkè na usoro ntụgharị asụsụ site n'ịghọta kpọmkwem codons na ibuga amino acid kwekọrọ na ribosome.

Metabolism: Uridine nwere ike ịmepụta de novo n'ime sel ma ọ bụ nweta ya site na isi mmalite nri. A na-emepụta ya site na ntụgharị enzymatic nke orotidine monophosphate (OMP) ma ọ bụ uridine monophosphate (UMP) na ụzọ biosynthesis pyrimidine.

Mkpa anụ ahụ:

Neurotransmitter Precursor: Uridine na-ekere òkè na ọrụ ụbụrụ na mmepe. Ọ bụ ihe mmalite maka njikọ nke ụbụrụ phospholipids, gụnyere phosphatidylcholine, nke dị mkpa maka iguzosi ike n'ezi ihe nke akpụkpọ ahụ na neurotransmitter.

Mmetụta Neuroprotective: A mụọla Uridine maka ihe ndị nwere ike ime ihe na-eme ka ọ dịkwuo mma na ike ime ka ọrụ synapti na-arụ ọrụ na plasticity neuronal.

Enwere ike ọgwụgwọ:

A nyochala Uridine na ihe ndị sitere na ya maka ngwa ọgwụgwọ nwere ike ime na nsogbu akwara ozi, gụnyere ọrịa Alzheimer na nsogbu ọnọdụ uche.

Achọpụtala ihe mgbakwunye Uridine dị ka atụmatụ iji kwado ọrụ ọgụgụ isi na ibelata mgbaàmà ndị metụtara ọrịa neurodegenerative.

Isi mmalite nri: A na-ahụ Uridine na nri dị iche iche, gụnyere anụ, azụ, akwụkwọ nri, na ngwaahịa mmiri ara ehi.